Hit and Lead Finding Libraries

The focus for our library and building block design is to provide compounds and reagents suitable for generating Hit Finding and Fragment Based Discovery (FBD) libraries. Our design work is focussed on saturated ring systems (or saturated rings linked to heterocycles) since we believe that saturation confers increased novelty, aqueous solubility, three dimensional complexity, and a favorable balance between hydrophilicity and lipophilicity.

Quality Control: We provide CoAs  [and MSDS] with each compound and retain analytical samples which we  periodically re-analyze to confirm shelf-life. CoAs confirm purity exceeding 95% (area) by HPLC. 1H NMR is used to quantify residual solvent or water content for each compound. Structural confirmation is achieved by LC-MS and 1H NMR.